Ontology highlight
ABSTRACT:
SUBMITTER: Peterson DW
PROVIDER: S-EPMC2840295 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Peterson Dylan W DW Ando D Michael DM Taketa Daryl A DA Zhou Hongjun H Dahlquist Fredrick W FW Lew John J
Proceedings of the National Academy of Sciences of the United States of America 20100201 7
CDK5/p35 is a cyclin-dependent kinase essential for normal neuron function. Proteolysis of the p35 subunit in vivo results in CDK5/p25 that causes neurotoxicity associated with a number of neurodegenerative diseases. Whereas the mechanism by which conversion of p35 to p25 leads to toxicity is unknown, there is common belief that CDK5/p25 is catalytically hyperactive compared to CDK5/p35. Here, we have compared the steady-state kinetic parameters of CDK5/p35 and CDK5/p25 towards both histone H1, ...[more]