Ontology highlight
ABSTRACT:
SUBMITTER: Wolf MC
PROVIDER: S-EPMC2840368 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Wolf Mike C MC Freiberg Alexander N AN Zhang Tinghu T Akyol-Ataman Zeynep Z Grock Andrew A Hong Patrick W PW Li Jianrong J Watson Natalya F NF Fang Angela Q AQ Aguilar Hector C HC Porotto Matteo M Honko Anna N AN Damoiseaux Robert R Miller John P JP Woodson Sara E SE Chantasirivisal Steven S Fontanes Vanessa V Negrete Oscar A OA Krogstad Paul P Dasgupta Asim A Moscona Anne A Hensley Lisa E LE Whelan Sean P SP Faull Kym F KF Holbrook Michael R MR Jung Michael E ME Lee Benhur B
Proceedings of the National Academy of Sciences of the United States of America 20100128 7
We describe an antiviral small molecule, LJ001, effective against numerous enveloped viruses including Influenza A, filoviruses, poxviruses, arenaviruses, bunyaviruses, paramyxoviruses, flaviviruses, and HIV-1. In sharp contrast, the compound had no effect on the infection of nonenveloped viruses. In vitro and in vivo assays showed no overt toxicity. LJ001 specifically intercalated into viral membranes, irreversibly inactivated virions while leaving functionally intact envelope proteins, and inh ...[more]