Ontology highlight
ABSTRACT:
SUBMITTER: Clauson CL
PROVIDER: S-EPMC2840506 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Clauson Cheryl L CL Oestreich Kenneth J KJ Austin James W JW Doetsch Paul W PW
Proceedings of the National Academy of Sciences of the United States of America 20100208 8
DNA damage occurs continuously, and faithful replication and transcription are essential for maintaining cell viability. Cells in nature are not dividing and replicating DNA often; therefore it is important to consider the outcome of RNA polymerase (RNAP) encounters with DNA damage. Base damage in the DNA can affect transcriptional fidelity, leading to production of mutant mRNA and protein in a process termed transcriptional mutagenesis (TM). Abasic (AP) sites and strand breaks are frequently oc ...[more]