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Tracking a molecular motor with a nanoscale optical encoder.

ABSTRACT: Optical encoders are commonly used in macroscopic machines to make precise measurements of distance and velocity by translating motion into a periodic signal. Here we show how Forster resonance energy transfer can be used to implement this technique at the single-molecule scale. We incorporate a series of acceptor dye molecules into self-assembling DNA, and the periodic signal resulting from unhindered motion of a donor-labeled molecular motor provides nanometer-scale resolution in milliseconds.

SUBMITTER: Wickersham CE 

PROVIDER: S-EPMC2842186 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature

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Tracking a molecular motor with a nanoscale optical encoder.

Wickersham Charles E CE   Cash Kevin J KJ   Pfeil Shawn H SH   Bruck Irina I   Kaplan Daniel L DL   Plaxco Kevin W KW   Lipman Everett A EA  

Nano letters 20100301 3

Optical encoders are commonly used in macroscopic machines to make precise measurements of distance and velocity by translating motion into a periodic signal. Here we show how Forster resonance energy transfer can be used to implement this technique at the single-molecule scale. We incorporate a series of acceptor dye molecules into self-assembling DNA, and the periodic signal resulting from unhindered motion of a donor-labeled molecular motor provides nanometer-scale resolution in milliseconds. ...[more]