Ontology highlight
ABSTRACT:
SUBMITTER: Menalled LB
PROVIDER: S-EPMC2842438 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Menalled Liliana B LB Patry Monica M Ragland Natalie N Lowden Phillip A S PA Goodman Jennifer J Minnich Jennie J Zahasky Benjamin B Park Larry L Leeds Janet J Howland David D Signer Ethan E Tobin Allan J AJ Brunner Daniela D
PloS one 20100322 3
Previous studies of the effects of coenzyme Q10 and minocycline on mouse models of Huntington's disease have produced conflicting results regarding their efficacy in behavioral tests. Using our recently published best practices for husbandry and testing for mouse models of Huntington's disease, we report that neither coenzyme Q10 nor minocycline had significant beneficial effects on measures of motor function, general health (open field, rotarod, grip strength, rearing-climbing, body weight and ...[more]