Ontology highlight
ABSTRACT:
SUBMITTER: Dugas JC
PROVIDER: S-EPMC2843397 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Dugas Jason C JC Cuellar Trinna L TL Scholze Anja A Ason Brandon B Ibrahim Adiljan A Emery Ben B Zamanian Jennifer L JL Foo Lynette C LC McManus Michael T MT Barres Ben A BA
Neuron 20100301 5
To investigate the role of microRNAs in regulating oligodendrocyte (OL) differentiation and myelination, we utilized transgenic mice in which microRNA processing was disrupted in OL precursor cells (OPCs) and OLs by targeted deletion of Dicer1. We found that inhibition of OPC-OL miRNA processing disrupts normal CNS myelination and that OPCs lacking mature miRNAs fail to differentiate normally in vitro. We identified three miRNAs (miR-219, miR-138, and miR-338) that are induced 10-100x during OL ...[more]