Nav2 is necessary for cranial nerve development and blood pressure regulation.
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ABSTRACT:
SUBMITTER: McNeill EM
PROVIDER: S-EPMC2843687 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Publications
Nav2 is necessary for cranial nerve development and blood pressure regulation.
McNeill Elizabeth M EM Roos Kenneth P KP Moechars Dieder D Clagett-Dame Margaret M
Neural development 20100225
<h4>Background</h4>All-trans retinoic acid (atRA) is required for nervous system development, including the developing hindbrain region. Neuron navigator 2 (Nav2) was first identified as an atRA-responsive gene in human neuroblastoma cells (retinoic acid-induced in neuroblastoma 1, Rainb1), and is required for atRA-mediated neurite outgrowth. In this paper, we explore the importance of Nav2 in nervous system development and function in vivo.<h4>Results</h4>Nav2 hypomorphic homozygous mutants sho ...[more]
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