Ontology highlight
ABSTRACT:
SUBMITTER: Smith P
PROVIDER: S-EPMC2844085 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Smith Peter P Zhou Bingsen B Ho Nam N Yuan Yate-Ching YC Su Leila L Tsai Shiou-Chuan SC Yen Yun Y
Biochemistry 20091101 46
Human p53R2 (hp53R2) is a 351-residue p53-inducible ribonucleotide reductase (RNR) small subunit. It shares >80% sequence identity with hRRM2, the small RNR subunit responsible for normal maintenance of the deoxyribonucleotide (dNTP) pool used for DNA replication, which is active during the S phase in a cell cycle-dependent fashion. But rather than cyclic dNTP synthesis, hp53R2 has been shown to supply dNTPs for DNA repair to cells in G0-G1 in a p53-dependent fashion. The first X-ray crystal str ...[more]