An oncogenic role for the multiple endocrine neoplasia type 1 gene in prostate cancer.
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ABSTRACT:
SUBMITTER: Paris PL
PROVIDER: S-EPMC2844124 | biostudies-literature | 2009
REPOSITORIES: biostudies-literature
Publications
An oncogenic role for the multiple endocrine neoplasia type 1 gene in prostate cancer.
Paris P L PL Sridharan S S Hittelman A B AB Kobayashi Y Y Perner S S Huang G G Simko J J Carroll P P Rubin M A MA Collins C C
Prostate cancer and prostatic diseases 20080909 2
Prostate cancer is the second leading cause of cancer related deaths in US men, largely because of metastasis, which is ultimately fatal. A better understanding of metastasis biology will lead to improved prognostication and therapeutics. We previously reported 11q13.1 gain was independently predictive of recurrence after radical prostatectomy. Multiple endocrine neoplasia I (MEN1) maps to this region of copy number gain in aggressive prostate tumors and was shown to be the only gene at this loc ...[more]
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