Ontology highlight
ABSTRACT:
SUBMITTER: Senatore A
PROVIDER: S-EPMC2844193 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Senatore Adriano A Spafford J David JD
The Journal of biological chemistry 20100107 10
Here we describe features of the first non-mammalian T-type calcium channel (LCa(v)3) expressed in vitro. This molluscan channel possesses combined biophysical properties that are reminiscent of all mammalian T-type channels. It exhibits T-type features such as "transient" kinetics, but the "tiny" label, usually associated with Ba(2+) conductance, is hard to reconcile with the "bigness" of this channel in many respects. LCa(v)3 is 25% larger than any voltage-gated ion channel expressed to date. ...[more]