Ontology highlight
ABSTRACT:
SUBMITTER: Richter R
PROVIDER: S-EPMC2845271 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Richter Ricarda R Rorbach Joanna J Pajak Aleksandra A Smith Paul M PM Wessels Hans J HJ Huynen Martijn A MA Smeitink Jan A JA Lightowlers Robert N RN Chrzanowska-Lightowlers Zofia M ZM
The EMBO journal 20100225 6
Bioinformatic analysis classifies the human protein encoded by immature colon carcinoma transcript-1 (ICT1) as one of a family of four putative mitochondrial translation release factors. However, this has not been supported by any experimental evidence. As only a single member of this family, mtRF1a, is required to terminate the synthesis of all 13 mitochondrially encoded polypeptides, the true physiological function of ICT1 was unclear. Here, we report that ICT1 is an essential mitochondrial pr ...[more]