Ontology highlight
ABSTRACT:
SUBMITTER: Martin RM
PROVIDER: S-EPMC2845425 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Martin Robert M RM Cardoso M Cristina MC
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091106 4
The condensation level of chromatin is controlled by epigenetic modifications and associated regulatory factors and changes throughout differentiation and cell cycle progression. To test whether changes of chromatin condensation levels per se affect access and binding of proteins, we used a hypertonic cell treatment. This shift to hyperosmolar medium increased nuclear calcium concentrations and induced a reversible chromatin condensation comparable to the levels in mitosis. However, this condens ...[more]