Ontology highlight
ABSTRACT:
SUBMITTER: Barash U
PROVIDER: S-EPMC2845434 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Barash Uri U Cohen-Kaplan Victoria V Arvatz Gil G Gingis-Velitski Svetlana S Levy-Adam Flonia F Nativ Ofer O Shemesh Ronen R Ayalon-Sofer Michal M Ilan Neta N Vlodavsky Israel I
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20091209 4
Heparanase is a mammalian endo-beta-d-glucuronidase that can cleave heparan sulfate side chains, an activity strongly implicated in tumor cell dissemination. The current study aimed to identify and characterize heparanase splice variants. LEADS, Compugen's alternative splicing modeling platform (Compugen, Tel Aviv, Israel), was used to search for splice variants in silico; tumor-derived cell lines (i.e., CAG myeloma) and tumor biopsies were utilized to validate T5 expression in vivo; signaling ( ...[more]