Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance.

ABSTRACT: Lysophosphatidic acid (LPA), a water-soluble phospholipid, has gained significant attention in recent years since the discovery that it acts as a potent signaling molecule with wide-ranging effects on many different target tissues. There are currently five identified G protein-coupled receptors for LPA and more are undergoing validation. The complexity of the expression pattern and signaling properties of LPA receptors results in multiple influences on developmental, physiological, and pathological processes. This review provides a summary of LPA receptor signaling and current views on the potential involvement of this pathway in human diseases that include cardiovascular, cancer, neuropathic pain, neuropsychiatric disorders, reproductive disorders, and fibrosis. The involvement of LPA sig

SUBMITTER: Lin ME 

PROVIDER: S-EPMC2845529 | biostudies-literature | 2010 Apr

REPOSITORIES: biostudies-literature