Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.
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ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC2845930 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
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Mutant LRRK2(R1441G) BAC transgenic mice recapitulate cardinal features of Parkinson's disease.
Li Yanping Y Liu Wencheng W Oo Tinmarla F TF Wang Lei L Tang Yi Y Jackson-Lewis Vernice V Zhou Chun C Geghman Kindiya K Bogdanov Mikhail M Przedborski Serge S Beal M Flint MF Burke Robert E RE Li Chenjian C
Nature neuroscience 20090607 7
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most common genetic cause of Parkinson's disease. We created a LRRK2 transgenic mouse model that recapitulates cardinal features of the disease: an age-dependent and levodopa-responsive slowness of movement associated with diminished dopamine release and axonal pathology of nigrostriatal dopaminergic projection. These mice provide a valid model of Parkinson's disease and are a resource for the investigation of pathogenesis and therapeutic ...[more]
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2016-02-10 | GSE77720 | GEO