Ontology highlight
ABSTRACT:
SUBMITTER: Ramakrishnan R
PROVIDER: S-EPMC2846048 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Ramakrishnan Rupal R Assudani Deepak D Nagaraj Srinivas S Hunter Terri T Cho Hyun-Il HI Antonia Scott S Altiok Soner S Celis Esteban E Gabrilovich Dmitry I DI
The Journal of clinical investigation 20100315 4
Cancer immunotherapy faces a serious challenge because of low clinical efficacy. Recently, a number of clinical studies have reported the serendipitous finding of high rates of objective clinical response when cancer vaccines are combined with chemotherapy in patients with different types of cancers. However, the mechanism of this phenomenon remains unclear. Here, we tested in mice several cancer vaccines and an adoptive T cell transfer approach to cancer immunotherapy in combination with severa ...[more]