Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA.
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ABSTRACT:
SUBMITTER: Sau SP
PROVIDER: S-EPMC2846108 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
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Optimized DNA-targeting using triplex forming C5-alkynyl functionalized LNA.
Sau Sujay P SP Kumar Pawan P Anderson Brooke A BA Østergaard Michael E ME Deobald Lee L Paszczynski Andrzej A Sharma Pawan K PK Hrdlicka Patrick J PJ
Chemical communications (Cambridge, England) 20091012 44
Triplex forming oligonucleotides (TFOs) modified with C5-alkynyl functionalized LNA (locked nucleic acid) monomers display extraordinary thermal affinity toward double stranded DNA targets, excellent discrimination of Hoogsteen-mismatched targets, and high stability against 3?-exonucleases. ...[more]
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