Ontology highlight
ABSTRACT:
SUBMITTER: Nolan EM
PROVIDER: S-EPMC2846400 | biostudies-literature | 2009 Jan
REPOSITORIES: biostudies-literature
Nolan Elizabeth M EM Walsh Christopher T CT
Chembiochem : a European journal of chemical biology 20090101 1
The conventional notion that peptides are poor candidates for orally available drugs because of protease-sensitive peptide bonds, intrinsic hydrophilicity, and ionic charges contrasts with the diversity of antibiotic natural products with peptide-based frameworks that are synthesized and utilized by Nature. Several of these antibiotics, including penicillin and vancomycin, are employed to treat bacterial infections in humans and have been best-selling therapeutics for decades. Others might provi ...[more]