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Absence of mutations in GJB2 (Connexin-26) gene in an ethnic group of southwest Iran.

ABSTRACT: BACKGROUND:The common GJB2 gene mutation (35delG) has been previously reported from Iranian patients that were affected with nonsyndromic autosomal recessive deafness. We, therefore, for the first time, investigated the prevalence and frequency of the GJB2 gene mutation in the Iranian deaf population with Arabian origins. MATERIALS AND METHODS:We amplified and sequenced the entire coding sequence of the GJB2 gene from 61 deaf patients and 26 control subjects. RESULT:None of the analyzed samples revealed deafness-associated mutation. CONCLUSION:This finding differs from several reports from Iran as we have focused on the GJB2 gene that possesses various mutations as the cause of congenital recessive deafness.

SUBMITTER: Galehdari H

PROVIDER: S-EPMC2846572 | biostudies-literature | 2009 Jan

REPOSITORIES: biostudies-literature

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Absence of mutations in GJB2 (Connexin-26) gene in an ethnic group of southwest Iran.

Galehdari Hamid H Foroughmand Ali Mohammad AM Soorki Maryam Naderi MN Mohammadian Gholamreza G

Indian journal of human genetics 20090101 1

<h4>Background</h4>The common GJB2 gene mutation (35delG) has been previously reported from Iranian patients that were affected with nonsyndromic autosomal recessive deafness. We, therefore, for the first time, investigated the prevalence and frequency of the GJB2 gene mutation in the Iranian deaf population with Arabian origins.<h4>Materials and methods</h4>We amplified and sequenced the entire coding sequence of the GJB2 gene from 61 deaf patients and 26 control subjects.<h4>Result</h4>None of ...[more]

PMID: 20407643

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Novel mutations in the connexin 26 gene (GJB2) that cause autosomal recessive (DFNB1) hearing loss.

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Evaluation of electrocardiographic parameters in patients with hearing loss genotyped for the connexin 26 gene (GJB2) mutations.

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Analysis of Genetic Variations in Connexin 26 ( <i>GJB2</i> ) Gene among Nonsyndromic Hearing Impairment: Familial Study.

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Frequency of c.35delG Mutation in <i>GJB2</i> Gene (Connexin 26) in Syrian Patients with Nonsyndromic Hearing Impairment.

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