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INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months.


ABSTRACT: Researchers have described the association of a common DNA polymorphism, rs7566605, near INSIG2 (insulin-induced gene 2) with obesity in multiple independent populations that include subjects ages 11-60 years.1 To our knowledge, no studies have examined the association of this polymorphism with weight status during early childhood. We explored the association of the rs7566605 polymorphism with weight-for-length among 319 children at 6 months and 3 years participating in Project Viva, a pre-birth cohort study. In contrast to studies of older individuals, CC homozygosity was associated with lower gain in weight-for-length z-score between birth and age 6 months than GG homozygosity or GC heterozygosity. At age 3, we did not find an association. The association of INSIG2 gene with obesity may change direction with age.

SUBMITTER: Wu AC 

PROVIDER: S-EPMC2846639 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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INSIG2 is Associated with Lower Gain in Weight-for-Length Between Birth and Age 6 Months.

Wu Ann Chen AC   Gillman Matthew W MW   Taveras Elsie M EM   Litonjua Augusto A AA  

Clinical medicine. Pediatrics 20090101


Researchers have described the association of a common DNA polymorphism, rs7566605, near INSIG2 (insulin-induced gene 2) with obesity in multiple independent populations that include subjects ages 11-60 years.1 To our knowledge, no studies have examined the association of this polymorphism with weight status during early childhood. We explored the association of the rs7566605 polymorphism with weight-for-length among 319 children at 6 months and 3 years participating in Project Viva, a pre-birth  ...[more]

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