Long-chain acyl-CoA synthetases and fatty acid channeling.
Ontology highlight
ABSTRACT:
SUBMITTER: Mashek DG
PROVIDER: S-EPMC2846691 | biostudies-literature | 2007 Aug
REPOSITORIES: biostudies-literature
Publications
Long-chain acyl-CoA synthetases and fatty acid channeling.
Mashek Douglas G DG Li Lei O LO Coleman Rosalind A RA
Future lipidology 20070801 4
Thirteen homologous proteins comprise the long-chain acyl-CoA synthetase (ACSL), fatty acid transport protein (FATP), and bubblegum (ACSBG) subfamilies that activate long-chain and very-long-chain fatty acids to form acyl-CoAs. Gain- and loss-of-function studies show marked differences in the ability of these enzymes to channel fatty acids into different pathways of complex lipid synthesis. Further, the ability of the ACSLs and FATPs to enhance cellular FA uptake does not always require these pr ...[more]
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