Ontology highlight
ABSTRACT:
SUBMITTER: Dumanis SB
PROVIDER: S-EPMC2846754 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Dumanis Sonya B SB Tesoriero Joseph A JA Babus Lenard W LW Nguyen Madeline T MT Trotter Justin H JH Ladu Mary Jo MJ Weeber Edwin J EJ Turner R Scott RS Xu Baoji B Rebeck G William GW Hoe Hyang-Sook HS
The Journal of neuroscience : the official journal of the Society for Neuroscience 20091201 48
The three human alleles of apolipoprotein E (APOE) differentially influence outcome after CNS injury and affect one's risk of developing Alzheimer's disease (AD). It remains unclear how ApoE isoforms contribute to various AD-related pathological changes (e.g., amyloid plaques and synaptic and neuron loss). Here, we systematically examined whether apoE isoforms (E2, E3, E4) exhibit differential effects on dendritic spine density and morphology in APOE targeted replacement (TR) mice, which lack AD ...[more]