Ontology highlight
ABSTRACT:
SUBMITTER: Park BY
PROVIDER: S-EPMC2847000 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Park Byung-Yong BY Saint-Jeannet Jean-Pierre JP
Developmental dynamics : an official publication of the American Association of Anatomists 20100401 4
The transcription factor Sox9 has been implicated in inner ear formation in several species. To investigate the long-term consequences of Sox9 depletion on inner ear development we analyzed the inner ear architecture of Sox9-depleted Xenopus tadpoles generated by injection of increasing amounts of Sox9 morpholino antisense oligonucleotides. We found that Sox9-depletion resulted in major defects in the development of vestibular structures, semicircular canals and utricle, while the ventrally loca ...[more]