Ontology highlight
ABSTRACT:
SUBMITTER: Dachsel JC
PROVIDER: S-EPMC2847049 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Mechanisms of ageing and development 20100206 3
LRRK2 mutations are recognized as the most frequent genetic cause of both familial and sporadic parkinsonism identified to date. A remarkable feature of this form of parkinsonism is the variable penetrance of symptom manifestation resulting in a wide range of age-at-onset in patients. Herein we use a functional approach to identify the Lrrk1 protein as a potential disease modifier demonstrating an interaction and heterodimer formation with Lrrk2. In addition, evaluation of LRRK1 variants in our ...[more]