Ontology highlight
ABSTRACT:
SUBMITTER: Letsolo BT
PROVIDER: S-EPMC2847243 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Letsolo Boitelo T BT Rowson Jan J Baird Duncan M DM
Nucleic acids research 20091221 6
Telomere fusion is an important mutational event that has the potential to lead to large-scale genomic rearrangements of the types frequently observed in cancer. We have developed single-molecule approaches to detect, isolate and characterize the DNA sequence of telomere fusion events in human cells. Using these assays, we have detected complex fusion events that include fusion with interstitial loci adjacent to fragile sites, intra-molecular rearrangements, and fusion events involving the telom ...[more]