Ontology highlight
ABSTRACT:
SUBMITTER: Sabido E
PROVIDER: S-EPMC2847404 | biostudies-literature | 2009 Sep
REPOSITORIES: biostudies-literature
Sabidó Eduard E Tarragó Teresa T Niessen Sherry S Cravatt Benjamin F BF Giralt Ernest E
Chembiochem : a European journal of chemical biology 20090901 14
Postproline proteases constitute a subset of serine proteases involved in the regulation of many signaling events and are emerging as promising therapeutic targets for prevalent diseases, such as diabetes and cancer. Therefore, monitoring their activity in different tissues and diverse physiological states would certainly facilitate the elucidation of their physiological role and the establishment of new therapeutic targets. Here, we have synthesized a dipeptidyl phosphonate activity-based probe ...[more]