Ontology highlight
ABSTRACT:
SUBMITTER: Yan Z
PROVIDER: S-EPMC2847587 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Molecular cell 20100301 6
FANCM remodels branched DNA structures and plays essential roles in the cellular response to DNA replication stress. Here, we show that FANCM forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF. We find that MHF stimulates DNA binding and replication fork remodeling by FANCM. In the cell, FANCM and MHF are rapidly recruited to forks stalled by DNA interstrand crosslinks, and both are required for cellular resistance to such lesions. In vertebrates, FANCM-MHF associates ...[more]