Ontology highlight
ABSTRACT:
SUBMITTER: Yan Z
PROVIDER: S-EPMC2847587 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Yan Zhijiang Z Delannoy Mathieu M Ling Chen C Daee Danielle D Osman Fekret F Muniandy Parameswary A PA Shen Xi X Oostra Anneke B AB Du Hansen H Steltenpool Jurgen J Lin Ti T Schuster Beatrice B Décaillet Chantal C Stasiak Andrzej A Stasiak Alicja Z AZ Stone Stacie S Hoatlin Maureen E ME Schindler Detlev D Woodcock Christopher L CL Joenje Hans H Sen Ranjan R de Winter Johan P JP Li Lei L Seidman Michael M MM Whitby Matthew C MC Myung Kyungjae K Constantinou Angelos A Wang Weidong W
Molecular cell 20100301 6
FANCM remodels branched DNA structures and plays essential roles in the cellular response to DNA replication stress. Here, we show that FANCM forms a conserved DNA-remodeling complex with a histone-fold heterodimer, MHF. We find that MHF stimulates DNA binding and replication fork remodeling by FANCM. In the cell, FANCM and MHF are rapidly recruited to forks stalled by DNA interstrand crosslinks, and both are required for cellular resistance to such lesions. In vertebrates, FANCM-MHF associates ...[more]