Structural comparisons of class I phosphoinositide 3-kinases.
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ABSTRACT:
SUBMITTER: Amzel LM
PROVIDER: S-EPMC2847604 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Publications
Structural comparisons of class I phosphoinositide 3-kinases.
Amzel L Mario LM Huang Chuan-Hsiang CH Mandelker Diana D Lengauer Christoph C Gabelli Sandra B SB Vogelstein Bert B
Nature reviews. Cancer 20080901 9
Class I phosphoinositide 3-kinases (PI3Ks) are lipid kinases that regulate cell growth. One of these kinases, PI3Kalpha, is frequently mutated in diverse tumour types. The recently determined structure of PI3Kalpha reveals features that distinguish this enzyme from related lipid kinases. In addition, wild-type PI3Kgamma differs from PI3Kalpha by a substitution identical to a PI3Kalpha oncogenic mutant (His1047Arg) that might explain the differences in the enzymatic activities of the normal and m ...[more]
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