Ontology highlight
ABSTRACT:
SUBMITTER: Stewart RC
PROVIDER: S-EPMC2847664 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Current opinion in microbiology 20100129 2
Protein histidine kinases (PHKs) function in Two Component Signaling pathways utilized extensively by bacteria and archaea. Many PHKs participate in three distinct, but interrelated signaling reactions: autophoshorylation, phosphotransfer (to a partner Response Regulator (RR) protein), and dephosphorylation of this RR. Detailed biochemical and structural characterization of several PHKs has revealed how the domains of these proteins can interact to assemble the three active sites that promote th ...[more]