The Erk2 MAPK regulates CD8 T cell proliferation and survival.
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ABSTRACT:
SUBMITTER: D'Souza WN
PROVIDER: S-EPMC2847891 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
The Erk2 MAPK regulates CD8 T cell proliferation and survival.
D'Souza Warren N WN Chang Chiung-Fang CF Fischer April M AM Li Manqing M Hedrick Stephen M SM
Journal of immunology (Baltimore, Md. : 1950) 20081201 11
The magnitude of T cell responses is determined by proliferation and survival decisions made by the responding cells. We now demonstrate that the Erk MAPK pathway plays a critical role in these cell fate decisions within CD8 T cells. While Erk1 is dispensable for all aspects of CD8 T cell activation, Erk2 is required for the proliferation of CD8 T cells activated in the absence of costimulation. Surprisingly, Erk2 is not required for proliferation following the addition of a costimulatory signal ...[more]
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