Ontology highlight
ABSTRACT:
SUBMITTER: Galy V
PROVIDER: S-EPMC284812 | biostudies-literature | 2003 Dec
REPOSITORIES: biostudies-literature
Galy Vincent V Mattaj Iain W IW Askjaer Peter P
Molecular biology of the cell 20030822 12
Nuclear pore complexes (NPCs) span the nuclear envelope and mediate communication between the nucleus and the cytoplasm. To obtain insight into the structure and function of NPCs of multicellular organisms, we have initiated an extensive analysis of Caenorhabditis elegans nucleoporins. Of 20 assigned C. elegans nucleoporin genes, 17 were found to be essential for embryonic development either alone or in combination. In several cases, depletion of nucleoporins by RNAi caused severe defects in nuc ...[more]