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ABSTRACT:
SUBMITTER: Takada K
PROVIDER: S-EPMC2848298 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Takada Kentaro K Imamura Nobutaka N Gustafson Kirk R KR Henrich Curtis J CJ
Bioorganic & medicinal chemistry letters 20100111 4
In previous work, botryllamides discovered from the marine ascidian Botryllus tyreus were characterized as selective inhibitors of the ABCG2 multidrug transporter. However, the structural basis for this activity could not be established. In this study, botryllamide F, the core botryllamide structure, and botryllamide G, the most potent botryllamide ABCG2 inhibitor, were synthesized along with a series of structural variants for evaluation of structure-activity relationships. The biological activ ...[more]