Ontology highlight
ABSTRACT:
SUBMITTER: De Feo CJ
PROVIDER: S-EPMC2848729 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
De Feo Christopher J CJ Mootien Sara S Unger Vinzenz M VM
The Journal of membrane biology 20100312 2
Membrane proteins of the CTR family mediate cellular copper uptake in all eukaryotic cells and have been shown to participate in uptake of platinum-based anticancer drugs. Despite their importance for life and the clinical treatment of malignancies, directed biochemical studies of CTR proteins have been difficult because high-resolution structural information is missing. Building on our recent 7A structure of the human copper transporter hCTR1, we present the results of an extensive tryptophan-s ...[more]