Unknown

Dataset Information

0

The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growth.


ABSTRACT: The hypothesis that Nogo-A (Reticulon 4A) and Nogo-66 receptor (NgR1) limit adult CNS axonal growth after injury is supported by both in vitro experiments and in vivo pharmacological studies. However, genetic assessment of the role of Nogo-A in corticospinal tract (CST) axons after spinal cord dorsal hemisection has yielded conflicting results. CST regeneration is detected in homozygous nogo-ab(trap/trap) mice, but not in nogo-ab(atg/atg) mice. CST regeneration is also present after pharmacological NgR blockade, but not in ngr1(-/-) mice. To assess the nogo-ab(atg) and ngr1-null alleles for other axon growth phenotypes, we created unilateral pyramidotomies and monitored the uninjured CST. There is robust pyramidotomy-induced growth of nogo-ab(atg/atg) and ngr1(-/-) CST axons into denervated cervical gray matter. This fiber growth correlates with recovery of fine motor skill in the affected forelimb. Thus nogo-ab and ngr1 play a modulated role in limiting CNS axonal growth across a spectrum of different tracts in various lesion models.

SUBMITTER: Cafferty WB 

PROVIDER: S-EPMC2848954 | biostudies-literature | 2006 Nov

REPOSITORIES: biostudies-literature

altmetric image

Publications

The Nogo-Nogo receptor pathway limits a spectrum of adult CNS axonal growth.

Cafferty William B J WB   Strittmatter Stephen M SM  

The Journal of neuroscience : the official journal of the Society for Neuroscience 20061101 47


The hypothesis that Nogo-A (Reticulon 4A) and Nogo-66 receptor (NgR1) limit adult CNS axonal growth after injury is supported by both in vitro experiments and in vivo pharmacological studies. However, genetic assessment of the role of Nogo-A in corticospinal tract (CST) axons after spinal cord dorsal hemisection has yielded conflicting results. CST regeneration is detected in homozygous nogo-ab(trap/trap) mice, but not in nogo-ab(atg/atg) mice. CST regeneration is also present after pharmacologi  ...[more]

Similar Datasets

| S-EPMC7762779 | biostudies-literature
| S-EPMC2807333 | biostudies-literature
| S-EPMC2855556 | biostudies-literature
| S-EPMC4853550 | biostudies-literature
| S-EPMC7328129 | biostudies-literature
| S-EPMC5770975 | biostudies-literature
| S-EPMC3323955 | biostudies-literature
| S-EPMC4291493 | biostudies-literature
2018-05-16 | GSE98974 | GEO
2017-10-01 | GSE92657 | GEO