Ontology highlight
ABSTRACT:
SUBMITTER: Cafferty WB
PROVIDER: S-EPMC2848954 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Cafferty William B J WB Strittmatter Stephen M SM
The Journal of neuroscience : the official journal of the Society for Neuroscience 20061101 47
The hypothesis that Nogo-A (Reticulon 4A) and Nogo-66 receptor (NgR1) limit adult CNS axonal growth after injury is supported by both in vitro experiments and in vivo pharmacological studies. However, genetic assessment of the role of Nogo-A in corticospinal tract (CST) axons after spinal cord dorsal hemisection has yielded conflicting results. CST regeneration is detected in homozygous nogo-ab(trap/trap) mice, but not in nogo-ab(atg/atg) mice. CST regeneration is also present after pharmacologi ...[more]