Ontology highlight
ABSTRACT:
SUBMITTER: Halaban R
PROVIDER: S-EPMC2848976 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Halaban Ruth R Zhang Wengeng W Bacchiocchi Antonella A Cheng Elaine E Parisi Fabio F Ariyan Stephan S Krauthammer Michael M McCusker James P JP Kluger Yuval Y Sznol Mario M
Pigment cell & melanoma research 20100210 2
BRAF(V600E/K) is a frequent mutationally active tumor-specific kinase in melanomas that is currently targeted for therapy by the specific inhibitor PLX4032. Our studies with melanoma tumor cells that are BRAF(V600E/K) and BRAF(WT) showed that, paradoxically, while PLX4032 inhibited ERK1/2 in the highly sensitive BRAF(V600E/K), it activated the pathway in the resistant BRAF(WT) cells, via RAF1 activation, regardless of the status of mutations in NRAS or PTEN. The persistently active ERK1/2 trigge ...[more]