Ontology highlight
ABSTRACT:
SUBMITTER: Ali FR
PROVIDER: S-EPMC2848977 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Journal of neurochemistry 20091026 1
Two distinct variable number tandem repeats (VNTRs) within the human serotonin transporter gene (SLC6A4) have been implicated as predisposing factors for CNS disorders. The linked polymorphic region in the 5'-promoter exists as short (s) and long (l) alleles of a 22 or 23 bp elements. The second within intron 2 (Stin2) exists as three variants containing 9, 10 or 12 copies of a 16 or 17 bp element. These VNTRs, individually or in combination, supported differential reporter gene expression in ra ...[more]