Ontology highlight
ABSTRACT:
SUBMITTER: Walker E
PROVIDER: S-EPMC2849004 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Walker Emily E Chang Wing Y WY Hunkapiller Julie J Cagney Gerard G Garcha Kamal K Torchia Joseph J Krogan Nevan J NJ Reiter Jeremy F JF Stanford William L WL
Cell stem cell 20100201 2
Polycomb group (PcG) proteins are conserved epigenetic transcriptional repressors that control numerous developmental gene expression programs and have recently been implicated in modulating embryonic stem cell (ESC) fate. We identified the PcG protein PCL2 (polycomb-like 2) in a genome-wide screen for regulators of self-renewal and pluripotency and predicted that it would play an important role in mouse ESC-fate determination. Using multiple biochemical strategies, we provide evidence that PCL2 ...[more]