A Wnt oscillator model for somitogenesis.
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ABSTRACT:
SUBMITTER: Jensen PB
PROVIDER: S-EPMC2849083 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Publications
A Wnt oscillator model for somitogenesis.
Jensen Peter B PB Pedersen Lykke L Krishna Sandeep S Jensen Mogens H MH
Biophysical journal 20100301 6
We propose a model for the segmentation clock in vertebrate somitogenesis, based on the Wnt signaling pathway. The core of the model is a negative feedback loop centered around the Axin2 protein. Axin2 is activated by beta-catenin, which in turn is degraded by a complex of GSK3beta and Axin2. The model produces oscillatory states of the involved constituents with typical time periods of a few hours (ultradian oscillations). The oscillations are robust to changes in parameter values and are often ...[more]
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