Ontology highlight
ABSTRACT:
SUBMITTER: Szodorai A
PROVIDER: S-EPMC2849269 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
Szodorai Anita A Kuan Yung-Hui YH Hunzelmann Silke S Engel Ulrike U Sakane Ayuko A Sasaki Takuya T Takai Yoshimi Y Kirsch Joachim J Müller Ulrike U Beyreuther Konrad K Brady Scott S Morfini Gerardo G Kins Stefan S
The Journal of neuroscience : the official journal of the Society for Neuroscience 20091101 46
The amyloid precursor protein (APP) is anterogradely transported by conventional kinesin in a distinct transport vesicle, but both the biochemical composition of such a vesicle and the specific kinesin-1 motor responsible for transport are poorly defined. APP may be sequentially cleaved by beta- and gamma-secretases leading to accumulation of beta-amyloid (Abeta) peptides in brains of Alzheimer's disease patients, whereas cleavage of APP by alpha-secretases prevents Abeta generation. Here, we de ...[more]