Ontology highlight
ABSTRACT:
SUBMITTER: Dallmann HG
PROVIDER: S-EPMC2849275 | biostudies-literature | 2010 Mar
REPOSITORIES: biostudies-literature
Dallmann H Garry HG Fackelmayer Oliver J OJ Tomer Guy G Chen Joe J Wiktor-Becker Anna A Ferrara Tracey T Pope Casey C Oliveira Marcos T MT Burgers Peter M J PM Kaguni Laurie S LS McHenry Charles S CS
Biochemistry 20100301 11
Typically, biochemical screens that employ pure macromolecular components focus on single targets or a small number of interacting components. Researches rely on whole cell screens for more complex systems. Bacterial DNA replicases contain multiple subunits that change interactions with each stage of a complex reaction. Thus, the actual number of targets is a multiple of the proteins involved. It is estimated that the overall replication reaction includes up to 100 essential targets, many suitab ...[more]