Species-specific inhibition of foamy viruses from South American monkeys by New World Monkey TRIM5{alpha} proteins.
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ABSTRACT:
SUBMITTER: Pacheco B
PROVIDER: S-EPMC2849481 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Species-specific inhibition of foamy viruses from South American monkeys by New World Monkey TRIM5{alpha} proteins.
Pacheco Beatriz B Finzi Andrés A McGee-Estrada Kathleen K Sodroski Joseph J
Journal of virology 20100203 8
Foamy virus evolution closely parallels that of the host species, indicating virus-host coadaptation. We studied simian foamy viruses (SFVs) from common marmosets, spider monkeys, and squirrel monkeys, New World monkey (NWM) species that share geographic ranges. The TRIM5alpha protein from each of these NWM species inhibited the replication of at least one of the SFVs associated with the other two species but did not affect the replication of its own SFV. Thus, TRIM5alpha has potentially shaped ...[more]
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