Rapid diagnosis of azole-resistant aspergillosis by direct PCR using tissue specimens.
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ABSTRACT:
SUBMITTER: van der Linden JW
PROVIDER: S-EPMC2849623 | biostudies-literature | 2010 Apr
REPOSITORIES: biostudies-literature
Publications
Rapid diagnosis of azole-resistant aspergillosis by direct PCR using tissue specimens.
van der Linden Jan W M JW Snelders Eveline E Arends Jan P JP Daenen Simon M SM Melchers Willem J G WJ Verweij Paul E PE
Journal of clinical microbiology 20100127 4
We report the use of PCR techniques on a formalin-fixed and paraffin-embedded tissue specimen for direct detection of one dominant azole resistance mechanism in a case of disseminated invasive aspergillosis. Rapid detection of mutations associated with azole resistance directly in tissue significantly reduces diagnostic delay. ...[more]
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