Ontology highlight
ABSTRACT:
SUBMITTER: Sos ML
PROVIDER: S-EPMC2849653 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Cancer research 20090407 8
Clinical resistance to epidermal growth factor receptor (EGFR) inhibition in lung cancer has been linked to the emergence of the EGFR T790M resistance mutation or amplification of MET. Additional mechanisms contributing to EGFR inhibitor resistance remain elusive. By applying combined analyses of gene expression, copy number, and biochemical analyses of EGFR inhibitor responsiveness, we identified homozygous loss of PTEN to segregate EGFR-dependent and EGFR-independent cells. We show that in EGF ...[more]