Dataset Information

Bves, a member of the Popeye domain-containing gene family.

ABSTRACT: Bves was discovered through subtractive screens designed to identify heart-enriched transcripts. Bves is a transmembrane protein that possesses a highly conserved structure among species of the animal kingdom. Various approaches have been used to elucidate the expression pattern of Bves mRNA and protein as well as its function in developing and mature organisms. Emerging evidence indicates that this protein is present in muscle and epithelia of developing embryos and the adult. In vitro functional studies predict a role in cell-cell interaction and/or adhesion. In vivo analysis of protein function is very limited at present, but recent work in Xenopus supports the importance of Bves in epithelial integrity. Presented in this review is a compilation of published findings concerning Bves gene and protein characteristics, expression patterns in embryos and cells, and functional significance as determined thus far. Presently, the literature supports a hypothesis that Bves is essential to the junctional architecture of muscle and epithelial cell types. Although there remain aspects of Bves structure, expression, and function that are not completely resolved, now is an appropriate time to summarize current knowledge about this protein, the remaining questions, and what its potential role in development might be. This review will serve as a departure point for others who become interested in the study of this highly conserved protein.

SUBMITTER: Osler ME

PROVIDER: S-EPMC2849751 | biostudies-literature | 2006 Mar

REPOSITORIES: biostudies-literature

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Bves, a member of the Popeye domain-containing gene family.

Osler Megan E ME Smith Travis K TK Bader David M DM

Developmental dynamics : an official publication of the American Association of Anatomists 20060301 3

Bves was discovered through subtractive screens designed to identify heart-enriched transcripts. Bves is a transmembrane protein that possesses a highly conserved structure among species of the animal kingdom. Various approaches have been used to elucidate the expression pattern of Bves mRNA and protein as well as its function in developing and mature organisms. Emerging evidence indicates that this protein is present in muscle and epithelia of developing embryos and the adult. In vitro function ...[more]

PMID: 16444674

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Project description:The Popeye domain containing (POPDC) gene family consists of POPDC1 (also known as BVES), POPDC2 and POPDC3 and encodes a novel class of cyclic adenosine monophosphate (cAMP) effector proteins. Despite first reports of their isolation and initial characterization at the protein level dating back 20 years, only recently major advances in defining their biological functions and disease association have been made. Loss-of-function experiments in mice and zebrafish established an important role in skeletal muscle regeneration, heart rhythm control and stress signaling. Patients suffering from muscular dystrophy and atrioventricular block were found to carry missense and nonsense mutations in either of the three POPDC genes, which suggests an important function in the control of striated muscle homeostasis. However, POPDC genes are also expressed in a number of epithelial cells and function as tumor suppressor genes involved in the control of epithelial structure, tight junction formation and signaling. Suppression of POPDC genes enhances tumor cell proliferation, migration, invasion and metastasis in a variety of human cancers, thus promoting a malignant phenotype. Moreover, downregulation of POPDC1 and POPDC3 expression in different cancer types has been associated with poor prognosis. However, high POPDC3 expression has also been correlated to poor clinical prognosis in head and neck squamous cell carcinoma, suggesting that POPDC3 potentially plays different roles in the progression of different types of cancer. Interestingly, a gain of POPDC1 function in tumor cells inhibits cell proliferation, migration and invasion thereby reducing malignancy. Furthermore, POPDC proteins have been implicated in the control of cell cycle genes and epidermal growth factor and Wnt signaling. Work in tumor cell lines suggest that cyclic nucleotide binding may also be important in epithelial cells. Thus, POPDC proteins have a prominent role in tissue homeostasis and cellular signaling in both epithelia and striated muscle.

Dataset Information

Bves, a member of the Popeye domain-containing gene family.

Publications

Bves, a member of the Popeye domain-containing gene family.

Similar Datasets

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