Ontology highlight
ABSTRACT:
SUBMITTER: Steinmetz NF
PROVIDER: S-EPMC2849976 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Steinmetz Nicole F NF Manchester Marianne M
Biomacromolecules 20090401 4
PEGylation is an effective strategy for reducing biospecific interactions for pharmaceuticals. The plant virus Cowpea mosaic virus (CPMV) has been studied for potential nanobiomedical applications by virtue of its natural interactions with mammalian endothelial cells. To investigate the degree of PEGylation required to retarget CPMV-based formulations to other destinations, two CPMV-PEG formulations, CPMV-PEG1000 (P1) and CPMV-PEG2000 (P2) were tested. Modeling suggested that the PEG chains were ...[more]