Lineage-specific differences in the amino acid substitution process.

ABSTRACT: In Darwinian evolution, mutations occur approximately at random in a gene, turned into amino acid mutations by the genetic code. Some mutations are fixed to become substitutions and some are eliminated from the population. Partitioning pairs of closely related species with complete genome sequences by average population size of each pair, we looked at the substitution matrices generated for these partitions and compared the substitution patterns between species. We estimated a population genetic model that relates the relative fixation probabilities of different types of mutations to the selective pressure and population size. Parameterizations of the average and distribution of selective pressures for different amino acid substitution types in different population size comparisons were ge

SUBMITTER: Huzurbazar S 

PROVIDER: S-EPMC2850115 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature