Ontology highlight
ABSTRACT:
SUBMITTER: Pfeufer A
PROVIDER: S-EPMC2850197 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Nature genetics 20100110 2
The electrocardiographic PR interval (or PQ interval) reflects atrial and atrioventricular nodal conduction, disturbances of which increase risk of atrial fibrillation. We report a meta-analysis of genome-wide association studies for PR interval from seven population-based European studies in the CHARGE Consortium: AGES, ARIC, CHS, FHS, KORA, Rotterdam Study, and SardiNIA (N = 28,517). We identified nine loci associated with PR interval at P < 5 x 10(-8). At the 3p22.2 locus, we observed two ind ...[more]