Ontology highlight
ABSTRACT:
SUBMITTER: Brandt GE
PROVIDER: S-EPMC2850591 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Brandt Gary E L GE Schmidt Matthew D MD Prisinzano Thomas E TE Blagg Brian S J BS
Journal of medicinal chemistry 20080925 20
Gedunin (1), a tetranortriterpenoid isolated from the Indian neem tree ( Azadirachta indica), was recently shown to manifest anticancer activity via inhibition of the 90 kDa heat shock protein (Hsp90) folding machinery and to induce the degradation of Hsp90-dependent client proteins similar to other Hsp90 inhibitors. The mechanism of action by which gedunin induces client protein degradation remains undetermined, however, prior studies have demonstrated that it does not bind competitively versus ...[more]