Ontology highlight
ABSTRACT:
SUBMITTER: Liu G
PROVIDER: S-EPMC2850604 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Liu Gaohua G Forouhar Farhad F Eletsky Alexander A Atreya Hanudatta S HS Aramini James M JM Xiao Rong R Huang Yuanpeng J YJ Abashidze Mariam M Seetharaman Jayaraman J Liu Jinfeng J Rost Burkhard B Acton Thomas T Montelione Gaetano T GT Hunt John F JF Szyperski Thomas T
Journal of structural and functional genomics 20081220 2
For cell regulation, E2-like ubiquitin-fold modifier conjugating enzyme 1 (Ufc1) is involved in the transfer of ubiquitin-fold modifier 1 (Ufm1), a ubiquitin like protein which is activated by E1-like enzyme Uba5, to various target proteins. Thereby, Ufc1 participates in the very recently discovered Ufm1-Uba5-Ufc1 ubiquination pathway which is found in metazoan organisms. The structure of human Ufc1 was solved by using both NMR spectroscopy and X-ray crystallography. The complementary insights o ...[more]