Ontology highlight
ABSTRACT:
SUBMITTER: Jagannathan M
PROVIDER: S-EPMC2851147 | biostudies-literature | 2009 Dec
REPOSITORIES: biostudies-literature
Jagannathan Madhumita M Hasturk Hatice H Liang Yanmei Y Shin Hyunjin H Hetzel Jeremy T JT Kantarci Alpdogan A Rubin Daniel D McDonnell Marie E ME McDonnell Marie E ME Van Dyke Thomas E TE Ganley-Leal Lisa M LM Nikolajczyk Barbara S BS
Journal of immunology (Baltimore, Md. : 1950) 20091116 11
Chronic systemic inflammation links periodontal disease and diabetes to increased incidence of serious comorbidities. Activation of TLRs, particularly TLR2 and TLR4, promotes chronic systemic inflammation. Human B cells have been generally thought to lack these TLRs. However, recent work showed that an increased percentage of circulating B cells from inflammatory disease patients express TLR2 and TLR4, and that TLR engagement on B cells resulted in unexpected changes in gene expression. New data ...[more]